Drug Discovery Database

 

Table 1 lists all of the drugs we have screened using our two-stage phenotype-based assays in scn1Lab (Dravet syndrome) mutant zebrafish.  Drugs indicated in PURPLE are positive hits e.g., suppression of spontaneous seizures in both the locomotion behavioral (stage 1) and EEG (stage 2) assays.  Antiepileptic drugs (AEDs) are indicated in bold font.

Full details of our screening process and results can be found in peer-reviewed lab publications (Baraban et al. Nat. Neurosci. 2013; Dinday and Baraban, eNeuro 2016; Griffin et al. Brain 2017).

Screening was performed by Matthew Dinday, Kyla Hamling and Aliesha Griffin.  Searchable database will be up-dated periodically.