Joseane Righes-Marafiga, PhD

I have dedicated my career to understanding the mechanisms underlying ictogenesis and epileptogenesis, conducting research that spans from receptor- and synapse-level changes to large-scale phenomena such as seizure propagation and network oscillatory interactions across brain regions. My expertise encompasses a broad range of techniques, including the use of mouse and rat models of epilepsy—both chronic and acute acquired models (pilocarpine, kainic acid, and pentylenetetrazol)—as well as in vitro and in vivo pharmacological assays for drug screening, efficacy, safety, and toxicity evaluations. I have developed skills in stereotaxic surgeries for CNS drug delivery, EEG implantation, alongside in vitro electrophysiology techniques such as extracellular recordings, multi-whole-cell patch clamp and optogenetics. Additionally, I have experience conducting behavioral tests to evaluate seizures and its comorbidities. The guidance of my mentors, including Dr. Calcagnotto and Dr. Baraban, has been pivotal in my development as an epilepsy researcher, as have collaborations with leading scientists such as Dr. Rosalia Paterno (University of Oklahoma), Dr. Cristina Reschke (Royal College of Surgeons in Ireland), and Dr. Robert Hunt (University of California, Irvine). These experiences have cultivated my growth within collaborative and supportive scientific environments. Inspired by their mentorship and advancements, I am motivated to pursue innovative therapeutic strategies to improve outcomes for patients with epilepsy. During my postdoctoral training, I have actively sought opportunities to expand my expertise in electrophysiology and cell-therapy approaches while enhancing my skills in science advocacy, networking, and teaching.